What is oxidative stress?

Oxidative stress happens when there is an imbalance between the production of free radicals and the body’s ability to get rid of them. The liver and things like glutathione are built in protection methods for our body to be able to handle oxidative stress.

Can oxidative stress be a trigger for Epstein – Barr virus reactivation?

However, our bodies can only take so much. Oxidative stress levels are associated with reactivation of Epstein – Barr virus. With the new information that we have about glyphosate and its’ link to cancer along with the overwhelmingly new amount of cases of reactivated Epstein – Barr virus we cannot help, but wonder if there is a link here.

Does glyphosate cause oxidative stress?

A study on plants showed that glyphosate caused an increase in protein oxidation and glutathione activity, meaning that the glyphosate was causing oxidative stress, but further research needs to be done on the exact pathways that glyphosate influences.

We know that oxidative stress and mental/emotional stress can be a trigger for reactivating Epstein – Barr virus. Based on the widespread use of glyphosate, this could be something that sets the grounds for the body to no longer be able to keep Epstein – Barr virus at bay in a latent state.

What do glyphosate and Epstein – Barr virus have in common?

A recent study in 2019 looked into the link between pesticide exposure and the risk of non – Hodgkin lymphoid malignancies in agricultural study groups from France, Norway, and the USA. The study looked at the rate of non – Hodgkin lymphoma in farmers in association with 14 different pesticides. At first glance the rates did not seem statistically significant. There were 2430 non – Hodgkin’s lymphoma cases developed out of 316,270 farmers. However, upon further investigation there was an increase in prevalence of certain chemicals. One of which was glyphosate. Glyphosate was seen to be associated with diffuse large B-cell lymphoma more frequently than other pesticides.

Diffuse large b-cell lymphoma is the most common subtype of malignant lymphoma and has a history of being more aggressive when Epstein – Barr virus is present. Whether glyphosate and Epstein – Barr virus have an effect on the same pathways, feed into each other, or glyphosate directly increases the chance of Epstein – Barr virus reactivating is still to be determined. Based on this research it suggests once again that chronic illnesses are multi – faceted and that environmental toxin exposure should be considered when reactivated Epstein – Barr virus is present.

How to protect yourself

According to an article that was published in February 2019 that looked at the molecular patterns of Epstein – Barr virus, there are two pathways commonly affected by Epstein – Barr. They are the NF – kB and JAK/STAT pathway. Curcuminoids have been shown to act on the NF – kB pathway and are affective at fighting inflammation that may be caused in this pathway by the Epstein – Barr virus. Resveratrol has been seen to combat multiple forms of oxidative stress and dysregulation of the JAK/STAT pathway.

Along with this checking glyphosate levels can be done through The Great Plains Laboratory. Helping the body properly detoxify these can be done by:

  • Eating organic
  • Avoiding GMO products
  • Drinking purified water, make sure to check you well water
  • Make sure to be having 1 to 3 regular bowel movements per day
  • Sweating, use the sauna
  • Supporting antioxidant levels and glutathione

Minerals that have shown a direct action with glyphosate include Humic acid and Fulvic acid. As always with chronic conditions, this further shows that there are multiple factors affecting your health and that approaching all angles is key to achieving your health goals and getting you energetic and strong.

References

Arroyave JM, Waiman CC, Zanini GP, Avena MJ. Effect of humic acid on the adsorption/desorption behavior of glyphosate on goethite. Isotherms and kinetics. Chemosphere. 2016 Feb;145:34-41. doi: 10.1016/j.chemosphere.2015.11.082. Epub 2015 Dec 1.

de Freitas-Silva L, Rodríguez-Ruiz M, Houmani H, da Silva LC, Palma JM, Corpas FJ.

Glyphosate-induced oxidative stress in Arabidopsis thaliana affecting peroxisomal metabolism and triggers activity in the oxidative phase of the pentose phosphate pathway (OxPPP) involved in NADPH generation. J Plant Physiol. 2017 Nov;218:196-205. doi: 10.1016/j.jplph.2017.08.007. Epub 2017 Aug 31.

Duan GL, Wang CN, Liu YJ, Yu Q, Tang XL, Ni X, Zhu XY. Resveratrol alleviates endotoxemia-associated adrenal insufficiency by suppressing oxidative/nitrative stress. Endocr J. 2016 Jun 30;63(6):569-80. doi: 10.1507/endocrj.EJ15-0610. Epub 2016 Apr 7.

Leon ME, Schinasi LH, Lebailly P, Beane Freeman LE, Nordby KC Ferro G, Monnereau A, Brouwer M, Tual S, Baldi I, Kjaerheim K, Hofmann JN, Kristensen P, Koutros S, Straif K, Kromhout H, Schüz J. Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium.

Int J Epidemiol. 2019 Mar 18. pii: dyz017. doi: 10.1093/ije/dyz017. [Epub ahead of print]

Heslop HE. Biology and treatment of Epstein-Barr virus-associated non-Hodgkin lymphomas. Hematology Am Soc Hematol Educ Program. 2005:260-6.

Lu, Ting-Xun et al. “Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age.” Scientific reports vol. 5 12168. 23 Jul. 2015, doi:10.1038/srep12168